Tetraethylene glycol monomethyl ether

• CAT Number: I015624
• CAS Number: 23783-42-8
• Molecular Formula: C₉H₂₀O₅
• Molecular Weight: 208.25
• Purity: ≥95%
• Target: PROTAC Linkers
• Storage: Room Temperature
• IUPAC Name: 2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethanol
• InChI: InChI=1S/C9H20O5/c1-11-4-5-13-8-9-14-7-6-12-3-2-10/h10H,2-9H2,1H3
• InChIKey: ZNYRFEPBTVGZDN-UHFFFAOYSA-N
• SMILES: COCCOCCOCCOCCO

Tetraethylene glycol monomethyl ether (Cat No.:I015624) is a polyethylene glycol (PEG)-based linker commonly used in the synthesis of Proteolysis Targeting Chimeras (PROTACs). It serves as a crucial component in connecting the ligand for the target protein with the ligand for the E3 ubiquitin ligase, facilitating the targeted degradation of specific proteins within cells. TEG-Me possesses favorable solubility, stability, and biocompatibility properties, making it an ideal linker for PROTAC design. Its use in PROTAC synthesis enables the development of innovative therapeutic strategies for diseases by selectively eliminating disease-causing proteins at the molecular level.

Reference

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562