Tetraethylene glycol monotosylate

• CAT Number: I017203
• CAS Number: 77544-60-6
• Molecular Formula: C₁₅H₂₄O₇S
• Molecular Weight: 348.41
• Purity: ≥95%
• Target: PROTAC

Tetraethylene glycol monotosylate(CAT: I017203) is a versatile and cleavable linker frequently employed in the synthesis of antibody-drug conjugates (ADCs). Its acylhydrazone-based structure allows for stable conjugation between the antibody and the cytotoxic payload, ensuring sufficient stability during circulation and targeted delivery to specific cells. However, under appropriate conditions, this linker can be cleaved, releasing the drug payload within the target cell and facilitating the desired therapeutic effect.

Reference

[1]. Park KD, et al. Useful tools for biomolecule isolation, detection, and identification: acylhydrazone-based cleavable linkers.Chem Biol. 2009 Jul 31;16(7):763-72.