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5609-49-4-Tetragastrin HCl Tetragastrin HCl

Tetragastrin HCl

For research use only. Not for therapeutic Use.

  • CAT Number: I037136
  • CAS Number: 5609-49-4
  • Molecular Formula: C29H37ClN6O6S
  • Molecular Weight: 633.16
  • Purity: 98%
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Related Small Molecules: JG26     Prothidathion     N-(4-(aminomethyl)-2,6-dimethylphenyl)-5-(2,5-dichlorophenyl)furan-2-carboxamide    

Tetragastrin HCl (Cat.No:I037136) is the HCl salt of Tetragastrin, the C-terminal tetrapeptide of gastrin. It is the smallest peptide fragment of gastrin which has the same physiological and pharmacological activity as gastrin.


Catalog Number I037136
CAS Number 5609-49-4
Synonyms

Tetragastrin hydrochloride; Tetragastrin HCl; Trp-Met-Asp-Phe hydrochloride;

Molecular Formula C29H37ClN6O6S
Purity 98%
Solubility Soluble in DMSO
Appearance Solid powder
Storage Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
IUPAC Name (S)-3-((S)-2-((S)-2-amino-3-(1H-indol-3-yl)propanamido)-4-(methylthio)butanamido)-4-oxo-4-(((S)-1-oxo-1-(phenylamino)propan-2-yl)amino)butanoic acid hydrochloride
InChI InChI=1S/C29H36N6O6S.ClH/c1-17(26(38)33-19-8-4-3-5-9-19)32-29(41)24(15-25(36)37)35-28(40)23(12-13-42-2)34-27(39)21(30)14-18-16-31-22-11-7-6-10-20(18)22;/h3-11,16-17,21,23-24,31H,12-15,30H2,1-2H3,(H,32,41)(H,33,38)(H,34,39)(H,35,40)(H,36,37);1H/t17-,21-,23-,24-;/m0./s1
InChIKey WHGNESKICGIAEC-WCFNAMMKSA-N
SMILES C[C@@H](C(NC1=CC=CC=C1)=O)NC([C@H](CC(O)=O)NC([C@H](CCSC)NC([C@H](CC2=CNC3=C2C=CC=C3)N)=O)=O)=O.[H]Cl
Reference

1: Tenma T, Yodoya E, Tashima S, Fujita T, Murakami M, Yamamoto A, Muranishi S. Development of new lipophilic derivatives of tetragastrin: physicochemical characteristics and intestinal absorption of acyl-tetragastrin derivatives in rats. Pharm Res. 1993 Oct;10(10):1488-92. PubMed PMID: 8272412.
2: Komuro Y, Ishihara K, Ohara S, Saigenji K, Hotta K. Effects of tetragastrin on mucus glycoprotein in rat gastric mucosal protection. Gastroenterol Jpn. 1992 Oct;27(5):597-603. PubMed PMID: 1385248.
3: Tatsuta M, Iishi H, Yamamura H, Taniguchi H. Inhibition by tetragastrin of experimental carcinogenesis in rat colon: effect of wheat bran consumption. Int J Cancer. 1988 Feb 15;41(2):239-42. PubMed PMID: 2828245.
4: Tatsuta M, Iishi H, Baba M, Taniguchi H. Effect of 6-hydroxydopamine on gastric carcinogenesis and tetragastrin inhibition of gastric carcinogenesis induced by N-methyl-N’-nitro-N-nitrosoguanidine in Wistar rats. Cancer Res. 1989 Aug 1;49(15):4199-203. PubMed PMID: 2501024.
5: Tatsuta M, Iishi H, Yamamura H, Taniguchi H. Enhancement by propranolol of the inhibitory effect of tetragastrin on gastric carcinogenesis induced by N-methyl-N’-nitro-N-nitrosoguanidine in Wistar rats. Cancer Res. 1987 Jan 1;47(1):111-4. PubMed PMID: 3791197.
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13: Tatsuta M, Iishi H, Yamamura H, Baba M, Yamamoto R, Taniguchi H. Effect of cimetidine on inhibition by tetragastrin of carcinogenesis induced by N-methyl-N’-nitro-N-nitrosoguanidine in Wistar rats. Cancer Res. 1988 Mar 15;48(6):1591-5. PubMed PMID: 3345530.
14: Komuro Y, Ichikawa T, Ishihara K, Saigenji K, Hotta K. Influence of L-365,260, a CCK-B/gastrin receptor antagonist, on tetragastrin-stimulated mucin metabolism in rat gastric mucosa. Pharmacology. 1999 Jul;59(1):11-20. PubMed PMID: 10352422.
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