Tetrahydrocurcumin

• CAT Number: I003318
• CAS Number: 36062-04-1
• Molecular Formula: C21H24O6
• Molecular Weight: 372.41
• Purity: ≥95%
• Target: Autophagy
• Solubility: DMSO: ≥ 3.6 mg/mL
• Storage: 3 years -20C powder
• IUPAC Name: 1,7-bis(4-hydroxy-3-methoxyphenyl)heptane-3,5-dione
• InChI: InChI=1S/C21H24O6/c1-26-20-11-14(5-9-18(20)24)3-7-16(22)13-17(23)8-4-15-6-10-19(25)21(12-15)27-2/h5-6,9-12,24-25H,3-4,7-8,13H2,1-2H3
• InChIKey: LBTVHXHERHESKG-UHFFFAOYSA-N
• SMILES: COC1=C(C=CC(=C1)CCC(=O)CC(=O)CCC2=CC(=C(C=C2)O)OC)O

Tetrahydrocurcumin (Cat No.:I003318) is a major metabolite of curcumin, the active compound found in turmeric. It exhibits various pharmacological activities, including antioxidant, anti-inflammatory, and anti-cancer effects. As a potent antioxidant, tetrahydrocurcumin scavenges free radicals and protects cells from oxidative damage. It also possesses anti-inflammatory properties by inhibiting pro-inflammatory mediators. Moreover, tetrahydrocurcumin has been investigated for its potential in the prevention and treatment of various diseases, including cancer, cardiovascular diseases, neurodegenerative disorders, and skin conditions. Its versatile pharmacological actions make it an interesting compound for further research and development in drug discovery and therapeutic applications.

Reference

[1]. Kang N, et al. Tetrahydrocurcumin induces G2/M cell cycle arrest and apoptosis involving p38 MAPK activation in human breast cancer cells. Food Chem Toxicol. 2014 May;67:193-200.
[2]. Aggarwal BB, et al. Curcumin Differs from Tetrahydrocurcumin for Molecular Targets, Signaling Pathways and Cellular Responses. Molecules. 2014 Dec 24;20(1):185-205.
[3]. Sangartit W, et al. Tetrahydrocurcumin Protects against Cadmium-Induced Hypertension, Raised Arterial Stiffness and Vascular Remodeling in Mice. PLoS One. 2014 Dec 11;9(12):e114908.
[4]. Tyagi N, et al. Tetrahydrocurcumin ameliorates homocysteinylated cytochrome-c mediated autophagy in hyperhomocysteinemia mice after cerebral ischemia. J Mol Neurosci. 2012 May;47(1):128-38.