Tetrahydrofuran fentanyl (hydrochloride)

• CAT Number: R066862
• Molecular Formula: C24H30N2O2 • HCl
• Molecular Weight: 415.21
• Purity: ≥95%
• Synonyms: N-(1-phenethylpiperidin-4-yl)-N-phenyltetrahydrofuran-2-carboxamide, monohydrochloride
• Storage: -20°C
• IUPAC Name: N-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]oxolane-2-carboxamide;hydrochloride
• InChI: InChI=1S/C24H30N2O2.ClH/c27-24(23-12-7-19-28-23)26(21-10-5-2-6-11-21)22-14-17-25(18-15-22)16-13-20-8-3-1-4-9-20;/h1-6,8-11,22-23H,7,12-19H2;1H
• InChIKey: MXBPPYCITLQUNV-UHFFFAOYSA-N
• SMILES: O=C(C1CCCO1)N(C2CCN(CCC3=CC=CC=C3)CC2)C4=CC=CC=C4.Cl

Tetrahydrofuran Fentanyl (Hydrochloride)(CAT: R066862) is a synthetic opioid and an analog of fentanyl, distinguished by the incorporation of a tetrahydrofuran ring in its chemical structure. This modification impacts its pharmacological properties, potentially altering its potency, receptor binding affinity, and metabolic stability compared to fentanyl. Like other fentanyl analogs, Tetrahydrofuran Fentanyl acts as a potent agonist at the mu-opioid receptors, producing strong analgesic effects, but also carrying a high risk of respiratory depression and overdose. The hydrochloride salt form enhances its solubility and stability, making it more suitable for pharmaceutical formulations or research applications. This compound is primarily encountered in forensic and toxicological contexts, particularly in relation to the illicit drug market, where fentanyl analogs have been associated with a significant number of overdose cases. Its potency and potential for misuse make it a focus of concern in public health and law enforcement efforts to combat opioid abuse.