Tetrahydromagnolol

• CAT Number: I011526
• CAS Number: 20601-85-8
• Molecular Formula: C18H22O2
• Molecular Weight: 270.37
• Purity: ≥95%
• Synonyms: 2-(2-hydroxy-5-propylphenyl)-4-propylphenol
• InChI: InChI=1S/C18H22O2/c1-3-5-13-7-9-17(19)15(11-13)16-12-14(6-4-2)8-10-18(16)20/h7-12,19-20H,3-6H2,1-2H3
• InChIKey: OYAQUBKYAKSHOA-UHFFFAOYSA-N
• SMILES: CCCC1=CC(=C(C=C1)O)C2=C(C=CC(=C2)CCC)O

Tetrahydromagnolol (Magnolignan), a main metabolite of Magnolol, is a potent and selective cannabinoid CB2 receptor agonist with an EC50 of 170 nM and a Ki of 416 nM. Tetrahydromagnolol possesses 20-fold more selective for CB2 receptor than CB1 receptor. Tetrahydromagnolol is also a weak GPR55 receptor antagonist[1].

Reference

[1]. Alexander Fuchs, et al. The natural product magnolol as a lead structure for the development of potent cannabinoid receptor agonists. PLoS One. 2013 Oct 30;8(10):e77739.
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