For research use only. Not for therapeutic Use.
Tetrazine-PEG7-amine hydrochloride is a cleavable 7 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Tetrazine-PEG7-amine (hydrochloride) is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
| Synonyms | 3-[2-[2-[2-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]-N-[[4-(1,2,4,5-tetrazin-3-yl)phenyl]methyl]propanamide;hydrochloride |
| Molecular Formula | C26H43ClN6O8 |
| Purity | ≥95% |
| InChI | InChI=1S/C26H42N6O8.ClH/c27-6-8-35-10-12-37-14-16-39-18-20-40-19-17-38-15-13-36-11-9-34-7-5-25(33)28-21-23-1-3-24(4-2-23)26-31-29-22-30-32-26;/h1-4,22H,5-21,27H2,(H,28,33);1H |
| InChIKey | YSPZOKYIHWWTJO-UHFFFAOYSA-N |
| SMILES | C1=CC(=CC=C1CNC(=O)CCOCCOCCOCCOCCOCCOCCOCCN)C2=NN=CN=N2.Cl |
| Reference | [1]. Beck A, et, al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. |
