Tetrazine-Ph-PEG5-NHS ester

• CAT Number: I016352
• CAS Number: 1682653-80-0
• Molecular Formula: C₂₇H₃₆N₆O₁₀
• Molecular Weight: 604.61
• Purity: ≥95%
• Target: PROTAC Linkers
• IUPAC Name: (2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[2-[3-oxo-3-[[4-(1,2,4,5-tetrazin-3-yl)phenyl]methylamino]propoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoate
• InChI: InChI=1S/C27H36N6O10/c34-23(28-19-21-1-3-22(4-2-21)27-31-29-20-30-32-27)7-9-38-11-13-40-15-17-42-18-16-41-14-12-39-10-8-26(37)43-33-24(35)5-6-25(33)36/h1-4,20H,5-19H2,(H,28,34)
• InChIKey: DUPHIQYIPUTDJS-UHFFFAOYSA-N
• SMILES: C1CC(=O)N(C1=O)OC(=O)CCOCCOCCOCCOCCOCCC(=O)NCC2=CC=C(C=C2)C3=NN=CN=N3

Tetrazine-Ph-PEG5-NHS ester（Cat No.:I016352）is a chemical compound used in bioconjugation and labeling applications, particularly in research related to drug delivery and molecular imaging. The tetrazine group is reactive with strained alkyne groups in bioorthogonal reactions, making it useful in click chemistry for linking biomolecules without interfering with biological systems. The PEG5 linker provides solubility and flexibility, while the NHS ester (N-hydroxysuccinimide) allows for covalent attachment to amine groups on proteins or other molecules. This compound has applications in targeted therapies, diagnostics, and the development of imaging agents for molecular studies.

Reference

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562