Tetrodotoxin citrate

• CAT Number: I002408
• CAS Number: 18660-81-6
• Molecular Formula: C17H25N3O15
• Molecular Weight: 511.4
• Purity: ≥95%
• Synonyms: ​TTX citrate
• Solubility: 100 mM in water
• Storage: -20°C
• IUPAC Name: (1S,5R,6R,7S,9S,11R,12S,13S,14S)-3-amino-14-(hydroxymethyl)-8,10-dioxa-2,4-diazatetracyclo[7.3.1.17,11.01,6]tetradec-3-ene-5,9,12,13,14-pentol;2-hydroxypropane-1,2,3-tricarboxylic acid
• InChI: InChI=1S/C11H17N3O8.C6H8O7/c12-8-13-6(17)2-4-9(19,1-15)5-3(16)10(2,14-8)7(18)11(20,21-4)22-5;7-3(8)1-6(13,5(11)12)2-4(9)10/h2-7,15-20H,1H2,(H3,12,13,14);13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/t2-,3-,4+,5-,6-,7+,9+,10+,11+;/m1./s1
• InChIKey: YUJWMDOXROTQCW-WNGAXIQVSA-N
• SMILES: C(C(=O)O)C(CC(=O)O)(C(=O)O)O.C(C1(C2C3C(N=C(NC34C(C1OC(C4O)(O2)O)O)N)O)O)O

Tetrodotoxin citrate (Cat.No:I002408) is a neurotoxin derived from certain marine organisms, such as pufferfish and some invertebrates. It blocks voltage-gated sodium channels, leading to nerve conduction inhibition and muscle paralysis. While highly toxic, tetrodotoxin citrate is also used in research to study nerve function and pain modulation mechanisms.

Reference

[1]. Ngoc AH, et al. Tetrodotoxin for moderate to severe cancer pain: a randomized, double blind, parallel design multicenter study.
J Pain Symptom Manage. 2008 Apr;35(4):420-9.