Tetrodotoxin

For research use only. Not for therapeutic Use.

  • CAT Number: I003550
  • CAS Number: 4368-28-9
  • Molecular Formula: C11H17N3O8
  • Molecular Weight: 319.3
  • Purity: ≥95%
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Tetrodotoxin (CAT: I003550) is a potent neurotoxin found in certain marine organisms, such as pufferfish, marine snails, and some species of octopus. It acts by blocking voltage-gated sodium channels, thereby inhibiting the propagation of action potentials in nerve cells. Tetrodotoxin is highly toxic and can cause paralysis and even death if ingested in sufficient quantities. Due to its ability to block nerve impulses, it has been studied for its potential applications in pain management and neurological research.


Catalog Number I003550
CAS Number 4368-28-9
Synonyms

Araregai Toxin;Maculotoxin;Tectin;TTX

Molecular Formula C11H17N3O8
Purity ≥95%
Solubility 10 mM in DMSO
Storage -20°C
InChIKey CFMYXEVWODSLAX-QOZOJKKESA-N
SMILES NC1=N[C@H](O)[C@@]2([H])[C@]3([H])[C@](CO)(O)[C@]([H])([C@@]4([H])O)O[C@@](O)(O3)[C@@H](O)[C@@]24N1
Reference

1: González-Cano R, Tejada Má, Artacho-Cordón A, Nieto FR, Entrena JM, Wood JN,
Cendán CM. Effects of Tetrodotoxin in Mouse Models of Visceral Pain. Mar Drugs.
2017 Jun 21;15(6). pii: E188. doi: 10.3390/md15060188. PubMed PMID: 28635651.

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2: Hong B, Chen H, Han J, Xie Q, He J, Bai K, Dong Y, Yi R. A Study of
11-[3H]-Tetrodotoxin Absorption, Distribution, Metabolism and Excretion (ADME) in
Adult Sprague-Dawley Rats. Mar Drugs. 2017 Jun 2;15(6). pii: E159. doi:
10.3390/md15060159. PubMed PMID: 28574462.
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3: Hagen NA, Cantin L, Constant J, Haller T, Blaise G, Ong-Lam M, du Souich P,
Korz W, Lapointe B. Tetrodotoxin for Moderate to Severe Cancer-Related Pain: A
Multicentre, Randomized, Double-Blind, Placebo-Controlled, Parallel-Design Trial.
Pain Res Manag. 2017;2017:7212713. doi: 10.1155/2017/7212713. Epub 2017 May 7.
PubMed PMID: 28555092; PubMed Central PMCID: PMC5438848.

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4: Magarlamov TY, Melnikova DI, Chernyshev AV. Tetrodotoxin-Producing Bacteria:
Detection, Distribution and Migration of the Toxin in Aquatic Systems. Toxins
(Basel). 2017 May 17;9(5). pii: E166. doi: 10.3390/toxins9050166. Review. PubMed
PMID: 28513564; PubMed Central PMCID: PMC5450714.
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5: Santamaria CM, Zhan C, McAlvin JB, Zurakowski D, Kohane DS. Tetrodotoxin,
Epinephrine, and Chemical Permeation Enhancer Combinations in Peripheral Nerve
Blockade. Anesth Analg. 2017 Jun;124(6):1804-1812. doi:
10.1213/ANE.0000000000002072. PubMed PMID: 28452816; PubMed Central PMCID:
PMC5438287.

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