For research use only. Not for therapeutic Use.
TFMB-(S)-2-HG is a potent inhibitor of the 5′-methylcytosine hydroxylase TET2. TFMB-(S)-2-HG also inhibits the EglN prolyl hydroxylases. TFMB-(S)-2-HG has the potential for the research of acute myeloid leukemia (AML)[1].
| Catalog Number | I037164 |
| CAS Number | 1445703-64-9 |
| Synonyms | [3-(trifluoromethyl)phenyl]methyl (2S)-5-oxooxolane-2-carboxylate |
| Molecular Formula | C13H11F3O4 |
| Purity | ≥95% |
| InChI | InChI=1S/C13H11F3O4/c14-13(15,16)9-3-1-2-8(6-9)7-19-12(18)10-4-5-11(17)20-10/h1-3,6,10H,4-5,7H2/t10-/m0/s1 |
| InChIKey | UXTLNUGKDZMPTC-JTQLQIEISA-N |
| SMILES | C1CC(=O)OC1C(=O)OCC2=CC(=CC=C2)C(F)(F)F |
| Reference | [1]. Losman JA, et al. (R)-2-hydroxyglutarate is sufficient to promote leukemogenesis and its effects are reversible. Science. 2013;339(6127):1621-1625. |
