TFMB-(S)-2-HG

• CAT Number: I037164
• CAS Number: 1445703-64-9
• Molecular Formula: C13H11F3O4
• Molecular Weight: 288.22
• Purity: ≥95%
• Synonyms: [3-(trifluoromethyl)phenyl]methyl (2S)-5-oxooxolane-2-carboxylate
• InChI: InChI=1S/C13H11F3O4/c14-13(15,16)9-3-1-2-8(6-9)7-19-12(18)10-4-5-11(17)20-10/h1-3,6,10H,4-5,7H2/t10-/m0/s1
• InChIKey: UXTLNUGKDZMPTC-JTQLQIEISA-N
• SMILES: C1CC(=O)OC1C(=O)OCC2=CC(=CC=C2)C(F)(F)F

TFMB-(S)-2-HG is a potent inhibitor of the 5′-methylcytosine hydroxylase TET2. TFMB-(S)-2-HG also inhibits the EglN prolyl hydroxylases. TFMB-(S)-2-HG has the potential for the research of acute myeloid leukemia (AML)[1].

Reference

[1]. Losman JA, et al. (R)-2-hydroxyglutarate is sufficient to promote leukemogenesis and its effects are reversible. Science. 2013;339(6127):1621-1625.
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