For research use only. Not for therapeutic Use.
TG 100572(CAT: I005220) is a multi-targeted kinase inhibitor with high potency against select growth factor receptor tyrosine kinases and Src family kinases. It exhibits IC₅₀ values of 2 nM, 7 nM, 2 nM, 1 nM, and 0.5 nM for VEGFR1, VEGFR2, FGFR1, Src, and Fyn kinases, respectively. This compound is widely used in oncology and angiogenesis research to explore signaling pathways involved in tumor progression, angiogenesis, and vascular permeability. Its broad target profile makes TG 100572 a valuable tool for preclinical studies aimed at understanding complex kinase signaling networks and developing targeted therapies for cancer and angiogenesis-related diseases.
| Catalog Number | I005220 |
| CAS Number | 867334-05-2 |
| Synonyms | 4-chloro-3-[5-methyl-3-[4-(2-pyrrolidin-1-ylethoxy)anilino]-1,2,4-benzotriazin-7-yl]phenol |
| Molecular Formula | C26H26ClN5O2 |
| Purity | ≥95% |
| Target | Src |
| Solubility | 10 mM in DMSO |
| Storage | Store at -20°C |
| IC50 | 2/7/2/1/0.5 nM (VEGFR1/VEGFR2/FGFR1/Src/Fyn) [1] |
| IUPAC Name | 4-chloro-3-[5-methyl-3-[4-(2-pyrrolidin-1-ylethoxy)anilino]-1,2,4-benzotriazin-7-yl]phenol |
| InChI | InChI=1S/C26H26ClN5O2/c1-17-14-18(22-16-20(33)6-9-23(22)27)15-24-25(17)29-26(31-30-24)28-19-4-7-21(8-5-19)34-13-12-32-10-2-3-11-32/h4-9,14-16,33H,2-3,10-13H2,1H3,(H,28,29,31) |
| InChIKey | AQSSMEORRLJZLU-UHFFFAOYSA-N |
| SMILES | CC1=CC(=CC2=C1N=C(N=N2)NC3=CC=C(C=C3)OCCN4CCCC4)C5=C(C=CC(=C5)O)Cl |
