For research use only. Not for therapeutic Use.
TG100-115（Cat No.:I004546） is a selective inhibitor of phosphoinositide 3-kinase gamma (PI3Kγ) and delta (PI3Kδ) with IC50 values of 83 nM and 235 nM, respectively. It exhibits minimal inhibitory effects on phosphoinositide 3-kinase alpha (PI3Kα) and beta (PI3Kβ). By specifically targeting PI3Kγ and PI3Kδ isoforms, TG100-115 can modulate signaling pathways involved in immune cell function and inflammation. This selective inhibition may have potential therapeutic applications in conditions such as autoimmune diseases and inflammatory disorders where PI3Kγ and PI3Kδ play significant roles.
| Catalog Number | I004546 |
| CAS Number | 677297-51-7 |
| Synonyms | 3-[2,4-diamino-7-(3-hydroxyphenyl)pteridin-6-yl]phenol |
| Molecular Formula | C₁₈H₁₄N₆O₂ |
| Purity | ≥95% |
| Target | PI3K |
| Solubility | DMSO ≥8.7mg/mL Water <1.2mg/mL Ethanol <1.2mg/mL |
| Storage | Store at -20°C |
| IUPAC Name | 3-[2,4-diamino-7-(3-hydroxyphenyl)pteridin-6-yl]phenol |
| InChI | InChI=1S/C18H14N6O2/c19-16-15-17(24-18(20)23-16)22-14(10-4-2-6-12(26)8-10)13(21-15)9-3-1-5-11(25)7-9/h1-8,25-26H,(H4,19,20,22,23,24) |
| InChIKey | UJIAQDJKSXQLIT-UHFFFAOYSA-N |
| SMILES | C1=CC(=CC(=C1)O)C2=NC3=C(N=C(N=C3N=C2C4=CC(=CC=C4)O)N)N |
| Reference | </br>1:Identification of TG100-115 as a new and potent TRPM7 kinase inhibitor, which suppresses breast cancer cell migration and invasion. Song C, Bae Y, Jun J, Lee H, Kim ND, Lee KB, Hur W, Park JY, Sim T.Biochim Biophys Acta. 2017 Apr;1861(4):947-957. doi: 10.1016/j.bbagen.2017.01.034. Epub 2017 Feb 1. PMID: 28161478 </br>2:Aerosolized phosphoinositide 3-kinase gamma/delta inhibitor TG100-115 [3-[2,4-diamino-6-(3-hydroxyphenyl)pteridin-7-yl]phenol] as a therapeutic candidate for asthma and chronic obstructive pulmonary disease. Doukas J, Eide L, Stebbins K, Racanelli-Layton A, Dellamary L, Martin M, Dneprovskaia E, Noronha G, Soll R, Wrasidlo W, Acevedo LM, Cheresh DA.J Pharmacol Exp Ther. 2009 Mar;328(3):758-65. doi: 10.1124/jpet.108.144311. Epub 2008 Dec 4. PMID: 19056934 Free Article |
