TG11-77 hydrochloride

• CAT Number: I047654
• CAS Number: 2550393-38-7
• Molecular Formula: C23H24N6O.HCl
• Molecular Weight: 436.94
• Purity: ≥95%
• IUPAC Name: 2-[(4,6-dimethylpyridin-2-yl)amino]-N-[2-(2-methyl-1H-indol-3-yl)ethyl]pyrimidine-5-carboxamide;hydrochloride
• InChI: InChI=1S/C23H24N6O.ClH/c1-14-10-15(2)27-21(11-14)29-23-25-12-17(13-26-23)22(30)24-9-8-18-16(3)28-20-7-5-4-6-19(18)20;/h4-7,10-13,28H,8-9H2,1-3H3,(H,24,30)(H,25,26,27,29);1H
• SMILES: CC1=CC(=NC(=C1)NC2=NC=C(C=N2)C(=O)NCCC3=C(NC4=CC=CC=C43)C)C.Cl

TG11-77 hydrochloride is a potent, selective, water soluble, brain-permeable EP2 receptor antagonist with a KB value of 9.7 nM.
KEYWORDS: TG11-77 hydrochloride | supplier | PGE receptor 2 (EP2) antagonist | TG11 77 hydrochloride | TG1177 hydrochloride | CAS [2550393-38-7] | [2490544-33-5] | Prostaglandins | PGE2 (EP2) | Antagonist | Receptors

Reference

R Amaradhi et al. Potent, Selective, Water Soluble, Brain-Permeable EP2 Receptor Antagonist for Use in Central Nervous System Disease Models. J Med Chem. 2020 Feb 13;63(3):1032-1050.