For research use only. Not for therapeutic Use.
TGN-073 is an AQP4 facilitator which enhanced glymphatic transport. Diffusion MRI measurements demonstrated an increase in the diffusive transport of water in the brain of TGN-073 treated rats.
KEYWORDS: TGN-073 | Supplier | AQP4 facilitator | TGN 073 | TGN 073 | CAS [877459-36-4] | Water | AQP | Inhibitor | Proteins | Alzheimer’s disease | Dementia | Traumatic brain injury | Astroglial water channel aquaporin
| Catalog Number | I047711 |
| CAS Number | 877459-36-4 |
| Molecular Formula | C18H16N2O3S |
| Purity | ≥95% |
| IUPAC Name | N-(3-phenylmethoxypyridin-2-yl)benzenesulfonamide |
| InChI | InChI=1S/C18H16N2O3S/c21-24(22,16-10-5-2-6-11-16)20-18-17(12-7-13-19-18)23-14-15-8-3-1-4-9-15/h1-13H,14H2,(H,19,20) |
| SMILES | C1=CC=C(C=C1)COC2=C(N=CC=C2)NS(=O)(=O)C3=CC=CC=C3 |
| Reference | VJ Huber et al. Aquaporin-4 facilitator TGN-073 promotes interstitial fluid circulation within the blood-brain barrier: [17O]H2O JJVCPE MRI study. Neuroreport. 2018 Jun 13;29(9):697-703. A Alghanimy et al. The effect of a novel AQP4 facilitator, TGN-073, on glymphatic transport captured by diffusion MRI and DCE-MRI. PLoS One. 2023 Mar 15;18(3):e0282955. |
