TGR-1202 hydrochloride

• CAT Number: I001920
• CAS Number: 1532533-78-0
• Molecular Formula: C31H25ClF3N5O3
• Molecular Weight: 608.01
• Purity: ≥95%
• Target: PI3K; Casein Kinase
• Solubility: No data available
• Storage: Store at -20°C
• IC50: 22.2 nM
• IUPAC Name: 2-[(1S)-1-[4-amino-3-(3-fluoro-4-propan-2-yloxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]ethyl]-6-fluoro-3-(3-fluorophenyl)chromen-4-one;hydrochloride
• InChI: InChI=1S/C31H24F3N5O3.ClH/c1-15(2)41-24-9-7-18(12-22(24)34)27-26-30(35)36-14-37-31(26)39(38-27)16(3)29-25(17-5-4-6-19(32)11-17)28(40)21-13-20(33)8-10-23(21)42-29;/h4-16H,1-3H3,(H2,35,36,37);1H/t16-;/m0./s1
• InChIKey: QGVUVMVWYWMZIR-NTISSMGPSA-N
• SMILES: C[C@@H](C1=C(C(=O)C2=C(O1)C=CC(=C2)F)C3=CC(=CC=C3)F)N4C5=NC=NC(=C5C(=N4)C6=CC(=C(C=C6)OC(C)C)F)N.Cl

TGR-1202 hydrochloride (Cat No.:I001920) is a selective inhibitor of phosphoinositide 3-kinase delta (PI3Kδ) and casein kinase-1 epsilon (CK1ε), both of which play key roles in cell survival, proliferation, and immune signaling. It is primarily used in the treatment of B-cell malignancies, such as chronic lymphocytic leukemia (CLL) and non-Hodgkin’s lymphoma (NHL). By targeting PI3Kδ, TGR-1202 blocks pathways that support cancer cell growth, while its CK1ε inhibition contributes to its anti-inflammatory properties. Its dual action offers a novel approach in managing hematologic cancers and immune-related disorders.

Reference

[1]. Swaroop Vakkalankaab, et al. Inhibition of PI3Kδ kinase by a selective, small molecule inhibitor suppresses B-cell proliferation and leukemic cell growth