For research use only. Not for therapeutic Use.
TH-Z145, a lipophilic bisphosphonate, is a FPPS inhibitor (IC50: 210 nM)[1].
TH-Z145 (20 μg, i.p.) exhibits strong prophylactic effects in a pathogenic influenza model[1].
| Catalog Number | I042612 |
| CAS Number | 2260887-57-6 |
| Synonyms | [2-(3-octoxyphenyl)-1-phosphonoethyl]phosphonic acid |
| Molecular Formula | C16H28O7P2 |
| Purity | ≥95% |
| InChI | InChI=1S/C16H28O7P2/c1-2-3-4-5-6-7-11-23-15-10-8-9-14(12-15)13-16(24(17,18)19)25(20,21)22/h8-10,12,16H,2-7,11,13H2,1H3,(H2,17,18,19)(H2,20,21,22) |
| InChIKey | PHLMZTHHBLJPRI-UHFFFAOYSA-N |
| SMILES | CCCCCCCCOC1=CC=CC(=C1)CC(P(=O)(O)O)P(=O)(O)O |
| Reference | [1]. Xia Y, et al. The Mevalonate Pathway Is a Druggable Target for Vaccine Adjuvant Discovery. Cell. 2018 Nov 1;175(4):1059-1073.e21. |
