For research use only. Not for therapeutic Use.
TH-Z93, a lipophilic bisphosphonate, is a FPPS inhibitor (IC50: 90 nM)[1].
TH-Z93 (20 μg, i.p.) exhibits strong prophylactic effects in a pathogenic influenza model[1].
| Catalog Number | I042613 |
| CAS Number | 2260887-09-8 |
| Synonyms | [[(4-hexoxypyridin-2-yl)amino]-phosphonomethyl]phosphonic acid |
| Molecular Formula | C12H22N2O7P2 |
| Purity | ≥95% |
| InChI | InChI=1S/C12H22N2O7P2/c1-2-3-4-5-8-21-10-6-7-13-11(9-10)14-12(22(15,16)17)23(18,19)20/h6-7,9,12H,2-5,8H2,1H3,(H,13,14)(H2,15,16,17)(H2,18,19,20) |
| InChIKey | NXVHNJBPVOSZAP-UHFFFAOYSA-N |
| SMILES | CCCCCCOC1=CC(=NC=C1)NC(P(=O)(O)O)P(=O)(O)O |
| Reference | [1]. Xia Y, et al. The Mevalonate Pathway Is a Druggable Target for Vaccine Adjuvant Discovery. Cell. 2018 Nov 1;175(4):1059-1073.e21. |
