TH10785

For research use only. Not for therapeutic Use.

  • CAT Number: I043386
  • CAS Number: 1002801-51-5
  • Molecular Formula: C17H21N3
  • Molecular Weight: 267.37
  • Purity: ≥95%
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TH10785 is a DNA glycosylase 1 (OGG1) activator, TH10785 can interact with the phenylalanine-319 and glycine-42 amino acids of OGG1 and increase the enzyme activity, generates β, δ-lyase enzymatic function. TH10785 can control the catalytic activity mediated by a nitrogen base within its molecular structure. TH10785 can be used for the research of various diseases and aging connected with DNA oxidative lesions[1].
TH10785 (6.25 μM, 30 min) induces a de novo β, δ-elimination in vitro, allowing for AP sites as new substrates[1].
TH10785 (10 μM, 0-2 min) allows OGG1 to increase DNA repair by addressing AP sites[1].
TH10785 (0-20 μM, 72 h) induces OGG1 β, δ-lyase activity shifts cells toward PNKP1 dependence[1].
TH10785 (2 μM) has affinity to OGG1 (KD=5.5 μM) increased when adding an AP site analog containing double-stranded DNA (KD=1.3 μM)[1].


Catalog Number I043386
CAS Number 1002801-51-5
Synonyms

N-cyclohexyl-2-cyclopropylquinazolin-4-amine

Molecular Formula C17H21N3
Purity ≥95%
InChI InChI=1S/C17H21N3/c1-2-6-13(7-3-1)18-17-14-8-4-5-9-15(14)19-16(20-17)12-10-11-12/h4-5,8-9,12-13H,1-3,6-7,10-11H2,(H,18,19,20)
InChIKey ZQMGQZOHIDOPCQ-UHFFFAOYSA-N
SMILES C1CCC(CC1)NC2=NC(=NC3=CC=CC=C32)C4CC4
Reference

[1]. Maurice Michel, et al. Small-molecule activation of OGG1 increases oxidative DNA damage repair by gaining a new function. Science. 2022 Jun 24;376(6600):1471-1476.
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