For research use only. Not for therapeutic Use.
TH10785 is a DNA glycosylase 1 (OGG1) activator, TH10785 can interact with the phenylalanine-319 and glycine-42 amino acids of OGG1 and increase the enzyme activity, generates β, δ-lyase enzymatic function. TH10785 can control the catalytic activity mediated by a nitrogen base within its molecular structure. TH10785 can be used for the research of various diseases and aging connected with DNA oxidative lesions[1].
TH10785 (6.25 μM, 30 min) induces a de novo β, δ-elimination in vitro, allowing for AP sites as new substrates[1].
TH10785 (10 μM, 0-2 min) allows OGG1 to increase DNA repair by addressing AP sites[1].
TH10785 (0-20 μM, 72 h) induces OGG1 β, δ-lyase activity shifts cells toward PNKP1 dependence[1].
TH10785 (2 μM) has affinity to OGG1 (KD=5.5 μM) increased when adding an AP site analog containing double-stranded DNA (KD=1.3 μM)[1].
Catalog Number | I043386 |
CAS Number | 1002801-51-5 |
Synonyms | N-cyclohexyl-2-cyclopropylquinazolin-4-amine |
Molecular Formula | C17H21N3 |
Purity | ≥95% |
InChI | InChI=1S/C17H21N3/c1-2-6-13(7-3-1)18-17-14-8-4-5-9-15(14)19-16(20-17)12-10-11-12/h4-5,8-9,12-13H,1-3,6-7,10-11H2,(H,18,19,20) |
InChIKey | ZQMGQZOHIDOPCQ-UHFFFAOYSA-N |
SMILES | C1CCC(CC1)NC2=NC(=NC3=CC=CC=C32)C4CC4 |
Reference | [1]. Maurice Michel, et al. Small-molecule activation of OGG1 increases oxidative DNA damage repair by gaining a new function. Science. 2022 Jun 24;376(6600):1471-1476. |