For research use only. Not for therapeutic Use.
TH1760 is a novel inhibitor against the NUDIX hydrolase NUDT15, sensitizing cells to 6-thioguanine through enhanced accumulation of 6-thio-(d)GTP in nucleic acids.
| Catalog Number | I037184 |
| Synonyms | TH1760; TH 1760; TH-1760; MKB; |
| Molecular Formula | C20H18N4O5S |
| Purity | 98% |
| Solubility | Soluble in DMSO |
| Appearance | Solid powder |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| IUPAC Name | 6-((4-(1H-indole-5-carbonyl)piperazin-1-yl)sulfonyl)benzo[d]oxazol-2(3H)-one |
| InChI | InChI=1S/C20H18N4O5S/c25-19(14-1-3-16-13(11-14)5-6-21-16)23-7-9-24(10-8-23)30(27,28)15-2-4-17-18(12-15)29-20(26)22-17/h1-6,11-12,21H,7-10H2,(H,22,26) |
| InChIKey | HNCVDRFFJZJQRW-UHFFFAOYSA-N |
| SMILES | O=C1OC2=CC(S(=O)(N3CCN(C(C4=CC5=C(NC=C5)C=C4)=O)CC3)=O)=CC=C2N1 |
| Reference | 1: Zhang SM, Desroses M, Hagenkort A, Valerie NCK, Rehling D, Carter M, Wallner O, Koolmeister T, Throup A, Jemth AS, Almlöf I, Loseva O, Lundbäck T, Axelsson H, Regmi S, Sarno A, Krämer A, Pudelko L, Bräutigam L, Rasti A, Göttmann M, Wiita E, Kutzner J, Schaller T, Kalderén C, Cázares-Körner A, Page BDG, Krimpenfort R, Eshtad S, Altun M, Rudd SG, Knapp S, Scobie M, Homan EJ, Berglund UW, Stenmark P, Helleday T. Development of a chemical probe against NUDT15. Nat Chem Biol. 2020 Oct;16(10):1120-1128. doi: 10.1038/s41589-020-0592-z. Epub 2020 Jul 20. PMID: 32690945. |
