TH34

• CAT Number: I019107
• CAS Number: 2196203-96-8
• Molecular Formula: C₁₅H₁₆N₂O₂
• Molecular Weight: 256.30
• Purity: ≥95%
• Target: Epigenetics
• IUPAC Name: 3-(benzylamino)-N-hydroxy-4-methylbenzamide
• InChI: InChI=1S/C15H16N2O2/c1-11-7-8-13(15(18)17-19)9-14(11)16-10-12-5-3-2-4-6-12/h2-9,16,19H,10H2,1H3,(H,17,18)
• InChIKey: PZBARTUEWCQNSN-UHFFFAOYSA-N
• SMILES: CC1=C(C=C(C=C1)C(=O)NO)NCC2=CC=CC=C2

TH34(Cat No.:I019107) is a compound that acts as an inhibitor of histone deacetylases 6, 8, and 10, with IC₅₀ values of 4.6 μM, 1.9 μM, and 7.7 μM, respectively. It demonstrates high selectivity towards these HDAC isoforms compared to HDAC1, HDAC2, and HDAC3. Studies have shown that TH34 induces programmed cell death in neuroblastoma cells through the activation of caspases, which are enzymes involved in the apoptosis pathway. Additionally, TH34 can cause cell cycle arrest in neuroblastoma cells. These findings suggest that TH34 holds potential as a therapeutic agent for the treatment of neuroblastoma and potentially other cancers.

Reference

[1]. Kolbinger FR, et al. The HDAC6/8/10 inhibitor TH34 induces DNA damage-mediated cell death in human high-grade neuroblastoma cell lines. Arch Toxicol. 2018 Aug;92(8):2649-2664.