TH470

For research use only. Not for therapeutic Use.

  • CAT Number: I042608
  • CAS Number: 2834739-51-2
  • Molecular Formula: C30H31N5O5S2
  • Molecular Weight: 605.73
  • Purity: ≥95%
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TH470 is a highly selective LIMK1/2 (LIM kinase1/2) inhibitor (LIMK1 IC50=9.8 nM; LIMK2 IC50=13 nM), and can be used in orphan disease research[1].
TH470 (0.05-5 μM; 12 h) inhibits the growth of neurite[1].


Catalog Number I042608
CAS Number 2834739-51-2
Synonyms

N-[2-[benzyl-[4-(phenylsulfamoyl)benzoyl]amino]ethyl]-2-(2-methylpropanoylamino)-1,3-thiazole-5-carboxamide

Molecular Formula C30H31N5O5S2
Purity ≥95%
InChI InChI=1S/C30H31N5O5S2/c1-21(2)27(36)33-30-32-19-26(41-30)28(37)31-17-18-35(20-22-9-5-3-6-10-22)29(38)23-13-15-25(16-14-23)42(39,40)34-24-11-7-4-8-12-24/h3-16,19,21,34H,17-18,20H2,1-2H3,(H,31,37)(H,32,33,36)
InChIKey YVPYJSSYGACUSE-UHFFFAOYSA-N
SMILES CC(C)C(=O)NC1=NC=C(S1)C(=O)NCCN(CC2=CC=CC=C2)C(=O)C3=CC=C(C=C3)S(=O)(=O)NC4=CC=CC=C4
Reference

[1]. Hanke T, et al. Development and Characterization of Type I, Type II, and Type III LIM-Kinase Chemical Probes. J Med Chem. 2022 Oct 13;65(19):13264-13287.
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