For research use only. Not for therapeutic Use.
TH6342 is a SAMHD1 modulator that binds to pretetrameric SAMHD1 and prevents its oligomerization and allosteric activation. SAMHD1 is a dNTP triphosphohydrolase and an HIV-1 restriction factor. SAMHD1 can limit the replication of retroviruses and DNA viruses and has antiviral effects. The inhibitory mechanism of TH6342 does not occupy the SAMHD1 nucleotide-binding pocket, gently binds the target, and functions as a chemical probe[1].
TH6342 (2.5, 10, 40 μM) blocks dGTP-induced SAMHD1 activation in a dose-dependent manne, without altering the stability of SAMHD1 to pronase treatment under 0.05-0.5 mM concentartion[1].
| Catalog Number | I040102 |
| Synonyms | 6-(2-chlorophenyl)-N-(2-pyridin-2-ylethyl)imidazo[1,2-a]pyrazin-8-amine |
| Molecular Formula | C19H16ClN5 |
| Purity | ≥95% |
| InChI | InChI=1S/C19H16ClN5/c20-16-7-2-1-6-15(16)17-13-25-12-11-23-19(25)18(24-17)22-10-8-14-5-3-4-9-21-14/h1-7,9,11-13H,8,10H2,(H,22,24) |
| InChIKey | FTFMOTBPKKYVAB-UHFFFAOYSA-N |
| SMILES | C1=CC=C(C(=C1)C2=CN3C=CN=C3C(=N2)NCCC4=CC=CC=N4)Cl |
| Reference | [1]. Zhang SM, et al. Identification and evaluation of small-molecule inhibitors against the dNTPase SAMHD1 via a comprehensive screening funnel. iScience. 2024 Jan 13;27(2):108907. |
