THAL-SNS-032

• CAT Number: I019172
• CAS Number: 2139287-33-3
• Molecular Formula: C₄₀H₅₂N₈O₁₀S₂
• Molecular Weight: 869.02
• Purity: ≥95%
• Storage: Store at -20°C
• IUPAC Name: N-[5-[(5-tert-butyl-1,3-oxazol-2-yl)methylsulfanyl]-1,3-thiazol-2-yl]-1-[2-[2-[2-[2-[2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]ethoxy]ethoxy]ethoxy]ethylamino]-2-oxoethyl]piperidine-4-carboxamide
• InChI: InChI=1S/C40H52N8O10S2/c1-40(2,3)29-21-43-32(58-29)24-59-33-22-44-39(60-33)46-35(51)25-9-13-47(14-10-25)23-31(50)42-12-16-56-18-20-57-19-17-55-15-11-41-27-6-4-5-26-34(27)38(54)48(37(26)53)28-7-8-30(49)45-36(28)52/h4-6,21-22,25,28,41H,7-20,23-24H2,1-3H3,(H,42,50)(H,44,46,51)(H,45,49,52)
• InChIKey: BXDZOYLPNAIDOC-UHFFFAOYSA-N
• SMILES: CC(C)(C)C1=CN=C(O1)CSC2=CN=C(S2)NC(=O)C3CCN(CC3)CC(=O)NCCOCCOCCOCCNC4=CC=CC5=C4C(=O)N(C5=O)C6CCC(=O)NC6=O

THAL-SNS-032（Cat No.:I019172） is a selective Cyclin-dependent kinase 9 (CDK9) degradation agent PROTAC, which contains a SNS-032 ligand that binds to CDK, a thalidomide derivative and E3ubiquitinligase Cereblon (CRBN).If you need, please feel free to contact us, we will reply to you within 24 hours.

Reference

[1]. Olson CM，et al. Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation. Nat Chem Biol. 2018 Feb;14(2):163-170.