Thalidomide 4'-oxyacetamide-alkyl-C2-amine hydrochloride

• CAT Number: I015250
• CAS Number: 2341841-02-7
• Molecular Formula: C17H19ClN4O6
• Molecular Weight: 410.81
• Purity: ≥95%
• Synonyms: N-(2-aminoethyl)-2-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]oxyacetamide;hydrochloride
• InChI: InChI=1S/C17H18N4O6.ClH/c18-6-7-19-13(23)8-27-11-3-1-2-9-14(11)17(26)21(16(9)25)10-4-5-12(22)20-15(10)24;/h1-3,10H,4-8,18H2,(H,19,23)(H,20,22,24);1H
• InChIKey: CVVNNSLQIHNBSU-UHFFFAOYSA-N
• SMILES: C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)OCC(=O)NCCN.Cl

Thalidomide 4′-oxyacetamide-alkyl-C2-amine hydrochloride incorporates a cereblon (CRBN) ligand for the E3 ubiquitin ligase, and a linker. Thalidomide 4′-oxyacetamide-alkyl-C2-amine hydrochloride can be used to design the PROTACs[1].

Reference

[1]. Zhou F, et al. Development of selective mono or dual PROTAC degrader probe of CDK isoforms. Eur J Med Chem. 2020;187:111952.
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