Thalidomide 5-fluoride

• CAT Number: I014840
• CAS Number: 835616-61-0
• Molecular Formula: C₁₃H₉FN₂O₄
• Molecular Weight: 276.22
• Purity: ≥95%
• Target: Autophagy

Thalidomide 5-fluoride(CAT: I014840) is a modified form of thalidomide that acts as a cereblon ligand. It is designed to bind to the protein IRAK4 (Interleukin-1 receptor-associated kinase 4) through a linker, forming a PROTAC (Proteolysis-targeting chimeras) molecule known as PROTAC IRAK4 degrader-1. This PROTAC molecule facilitates the degradation of IRAK4 through the ubiquitin-proteasome system, leading to targeted protein degradation. Thalidomide 5-fluoride offers a novel approach for modulating the activity of IRAK4 and potentially treating diseases associated with its dysregulation, such as certain types of cancer and inflammatory conditions.