Thalidomide-5-NH2-CH2-COOH

• CAT Number: I045038
• CAS Number: 2412056-27-8
• Molecular Formula: C15H13N3O6
• Molecular Weight: 331.28
• Purity: ≥95%
• Synonyms: 2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-5-yl]amino]acetic acid
• InChI: InChI=1S/C15H13N3O6/c19-11-4-3-10(13(22)17-11)18-14(23)8-2-1-7(16-6-12(20)21)5-9(8)15(18)24/h1-2,5,10,16H,3-4,6H2,(H,20,21)(H,17,19,22)
• InChIKey: ZATMCTCUKSYXHM-UHFFFAOYSA-N
• SMILES: C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C=C(C=C3)NCC(=O)O

Thalidomide-5-NH2-CH2-COOH (compound 114) is a potent and selective inhibitor of tropomyosin receptor kinase (trk). Thalidomide-5-NH2-CH2-COOH is a ligand of E3 ligase. Thalidomide-5-NH2-CH2-COOH has the potential for researching one or more diseases (extracted from patent WO2021170109A1)[1].

Reference

[1]. Jing Liu, et al. Tropomyosin receptor kinase (trk) degradation compounds and methods of use. Patent WO2021170109A1.