Thalidomide-5-PEG6-NH2 hydrochloride

• CAT Number: I040296
• Molecular Formula: C25H36ClN3O10
• Molecular Weight: 574.02
• Purity: ≥95%
• Synonyms: 5-[2-[2-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione;hydrochloride
• InChI: InChI=1S/C25H35N3O10.ClH/c26-5-6-33-7-8-34-9-10-35-11-12-36-13-14-37-15-16-38-18-1-2-19-20(17-18)25(32)28(24(19)31)21-3-4-22(29)27-23(21)30;/h1-2,17,21H,3-16,26H2,(H,27,29,30);1H
• InChIKey: FMOYKLLSJRTZNL-UHFFFAOYSA-N
• SMILES: C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C=C(C=C3)OCCOCCOCCOCCOCCOCCN.Cl

Thalidomide-5-PEG6-NH2 hydrochloride is the Thalidomide (HY-10984)-based cereblon ligand used in the recruitment of CRBN protein.Thalidomide-5-PEG6-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTACs[1].