Thalidomide-5-propargyl

• CAT Number: I040736
• CAS Number: 2226303-74-6
• Molecular Formula: C16H12N2O5
• Molecular Weight: 312.28
• Purity: ≥95%
• Synonyms: 2-(2,6-dioxopiperidin-3-yl)-5-prop-2-ynoxyisoindole-1,3-dione
• InChI: InChI=1S/C16H12N2O5/c1-2-7-23-9-3-4-10-11(8-9)16(22)18(15(10)21)12-5-6-13(19)17-14(12)20/h1,3-4,8,12H,5-7H2,(H,17,19,20)
• InChIKey: GDWXJPQKRQMMQW-UHFFFAOYSA-N
• SMILES: C#CCOC1=CC2=C(C=C1)C(=O)N(C2=O)C3CCC(=O)NC3=O

Thalidomide-5-propargyl(CAT: I040736) is a chemically modified derivative of thalidomide, featuring a propargyl group at the 5-position. This structural alteration enhances its utility in chemical biology and drug discovery, particularly in targeted protein degradation and PROTAC (Proteolysis Targeting Chimera) applications. The alkyne functionality enables click chemistry conjugation, facilitating the development of multifunctional molecules for therapeutic research. Retaining the immunomodulatory and anti-inflammatory backbone of thalidomide, this compound is valuable for exploring cereblon E3 ligase recruitment mechanisms. Thalidomide-5-propargyl is ideal for advanced studies in cancer, immunology, and molecular pharmacology, supporting innovative strategies in targeted therapeutics and molecular probe design.