Thalidomide-d4

• CAT Number: R005420
• CAS Number: 1219177-18-0
• Molecular Formula: C13H10N2O4
• Molecular Weight: 262.257
• Purity: ≥95%
• Synonyms: 2-(2,6-Dioxo-3-piperidinyl)-1H-iso-indole-1,3(2H)-dione-d4; α-Phthalimidoglutarimide-d4; 3-Phthalimidoglutarimide-d4; Celgene-d4; Contergan-d4; Distaval-d4; K 17-d4; Kevadon-d4; Myrin-d4; N-(2,6-Dioxo-3-piperidyl)phthalimide-d4; NSC 527179-d4; NSC 66
• Target: Autophagy
• Storage: -20°C
• IUPAC Name: 4,5,6,7-tetradeuterio-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione
• InChI: InChI=1S/C13H10N2O4/c16-10-6-5-9(11(17)14-10)15-12(18)7-3-1-2-4-8(7)13(15)19/h1-4,9H,5-6H2,(H,14,16,17)/i1D,2D,3D,4D
• InChIKey: UEJJHQNACJXSKW-RHQRLBAQSA-N
• SMILES: [2H]C1=C(C(=C2C(=C1[2H])C(=O)N(C2=O)C3CCC(=O)NC3=O)[2H])[2H]

Thalidomide-d4 is a deuterated form of thalidomide, a drug with immunomodulatory and anti-inflammatory properties, used to treat conditions such as multiple myeloma and leprosy. The four deuterium atoms replace hydrogen atoms in the molecule, providing a stable isotopic label that enhances precision in pharmacokinetic and metabolic studies. This compound is useful for tracking the drug’s absorption, distribution, metabolism, and excretion in biological systems. It is particularly valuable in research involving drug interactions, metabolism, and safety studies, as well as in optimizing therapeutic strategies and understanding the pharmacological profile of thalidomide.