Thalidomide-NH-C5-NH2 hydrochloride

• CAT Number: I015233
• CAS Number: 2375194-03-7
• Molecular Formula: C₁₈H₂₃ClN₄O₄
• Molecular Weight: 394.85
• Purity: ≥95%
• Target: Autophagy
• Storage: Store at -20°C
• IUPAC Name: 4-(5-aminopentylamino)-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione;hydrochloride
• InChI: InChI=1S/C18H22N4O4.ClH/c19-9-2-1-3-10-20-12-6-4-5-11-15(12)18(26)22(17(11)25)13-7-8-14(23)21-16(13)24;/h4-6,13,20H,1-3,7-10,19H2,(H,21,23,24);1H
• InChIKey: WJDRWFHGNHTFHU-UHFFFAOYSA-N
• SMILES: C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)NCCCCCN.Cl

Thalidomide-NH-C5-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate created by combining the Thalidomide-based cereblon ligand and a commonly used linker in PROTAC technology. This conjugate has been optimized for efficient degradation of targeted proteins and has potential therapeutic applications in cancer and other diseases.