Thalidomide-NH-PEG2-C2-NH-Boc

• CAT Number: I015163
• CAS Number: 2097509-40-3
• Molecular Formula: C₂₄H₃₂N₄O₈
• Molecular Weight: 504.53
• Purity: ≥95%
• Target: Autophagy
• IUPAC Name: tert-butyl N-[2-[2-[2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]ethoxy]ethoxy]ethyl]carbamate
• InChI: InChI=1S/C24H32N4O8/c1-24(2,3)36-23(33)26-10-12-35-14-13-34-11-9-25-16-6-4-5-15-19(16)22(32)28(21(15)31)17-7-8-18(29)27-20(17)30/h4-6,17,25H,7-14H2,1-3H3,(H,26,33)(H,27,29,30)
• InChIKey: YMOKYFTVZVHRSA-UHFFFAOYSA-N
• SMILES: CC(C)(C)OC(=O)NCCOCCOCCNC1=CC=CC2=C1C(=O)N(C2=O)C3CCC(=O)NC3=O

Thalidomide-NH-PEG2-C2-NH-Boc（Cat No.:I015163） is a synthetic conjugate consisting of a Thalidomide-based cereblon ligand and a PEG linker. It is utilized in the synthesis of dBRD9 (compound 6), which serves as a selective BRD9 probe PROTAC degrader. This compound is employed for the investigation of BAF (BRG1/BRM-associated factor) complex biology. By selectively degrading BRD9, dBRD9 allows researchers to study the role and function of the BAF complex, which is involved in various cellular processes and has implications in disease mechanisms.

Reference

[1]. David Remillard, et al. Degradation of the BAF Complex Factor BRD9 by Heterobifunctional Ligands.2017 May 15;56(21):5738-5743.