Thalidomide-NH-PEG3-NH-Boc

• CAT Number: I040761
• CAS Number: 2204246-03-5
• Molecular Formula: C26H36N4O9
• Molecular Weight: 548.59
• Purity: ≥95%
• Synonyms: tert-butyl N-[2-[2-[2-[2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]ethoxy]ethoxy]ethoxy]ethyl]carbamate
• InChI: InChI=1S/C26H36N4O9/c1-26(2,3)39-25(35)28-10-12-37-14-16-38-15-13-36-11-9-27-18-6-4-5-17-21(18)24(34)30(23(17)33)19-7-8-20(31)29-22(19)32/h4-6,19,27H,7-16H2,1-3H3,(H,28,35)(H,29,31,32)
• InChIKey: ZAQGFFFSCSRSDJ-UHFFFAOYSA-N
• SMILES: CC(C)(C)OC(=O)NCCOCCOCCOCCNC1=CC=CC2=C1C(=O)N(C2=O)C3CCC(=O)NC3=O

Thalidomide-NH-PEG3-NH-Boc(CAT: I040761) is a versatile bifunctional linker molecule widely used in the design of PROTACs (proteolysis-targeting chimeras) and other targeted drug delivery systems. It features a thalidomide moiety that binds to cereblon (CRBN), a substrate receptor of the E3 ubiquitin ligase complex, enabling targeted protein degradation. The PEG3 (triethylene glycol) spacer provides optimal flexibility, solubility, and reduced steric hindrance between functional domains. The Boc-protected amine allows for controlled deprotection and further functionalization during synthesis. Thalidomide-NH-PEG3-NH-Boc is a valuable tool in medicinal chemistry for developing next-generation therapeutics based on targeted protein degradation strategies.