Thalidomide-O-amido-C3-NH2 TFA

• CAT Number: I017977
• CAS Number: 2022182-58-5
• Molecular Formula: C₂₀H₂₁F₃N₄O₈
• Molecular Weight: 502.4
• Purity: ≥95%
• Target: Autophagy

Thalidomide-O-amido-C3-NH2 TFA (CAT: I017977) is a synthesized compound that acts as an E3 ligase ligand-linker conjugate. It combines a Thalidomide-based cereblon ligand with a linker molecule used in PROTAC (Proteolysis Targeting Chimeras) technology. PROTACs are small molecules designed to selectively degrade target proteins by recruiting them to E3 ligases for ubiquitination and subsequent degradation by the proteasome. Thalidomide-O-amido-C3-NH2 TFA is a designed compound aimed at utilizing the E3 ligase ligand and linker components to enable targeted protein degradation, potentially offering therapeutic applications in drug development.

Reference

[1]. Lohbeck J, et al. Practical synthesis of a phthalimide-based Cereblon ligand to enable PROTAC development. Bioorg Med Chem Lett. 2016 Nov 1;26(21):5260-5262.