Thalidomide-O-amido-PEG2-C2-NH2 hydrochloride

• CAT Number: I015418
• CAS Number: 2376990-30-4
• Molecular Formula: C₂₁H₂₇ClN₄O₈
• Molecular Weight: 498.91
• Purity: ≥95%
• Target: Autophagy

Thalidomide-O-amido-PEG2-C2-NH2 hydrochloride (Cat.No:I015418) incorporates an E3 ligase ligand and a linker, can be an immunomodulater for the treatment of cancer[1].PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Reference

[1]. ARYL SULFONOHYDRAZIDES. WO 2017/176958 A1.