For research use only. Not for therapeutic Use.
Thalidomide-O-C6-NHBoc is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].
| Catalog Number | I045224 |
| CAS Number | 2509093-23-4 |
| Synonyms | tert-butyl N-[6-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]oxyhexyl]carbamate |
| Molecular Formula | C24H31N3O7 |
| Purity | ≥95% |
| InChI | InChI=1S/C24H31N3O7/c1-24(2,3)34-23(32)25-13-6-4-5-7-14-33-17-10-8-9-15-19(17)22(31)27(21(15)30)16-11-12-18(28)26-20(16)29/h8-10,16H,4-7,11-14H2,1-3H3,(H,25,32)(H,26,28,29) |
| InChIKey | SWSPUYLZEIPCHI-UHFFFAOYSA-N |
| SMILES | CC(C)(C)OC(=O)NCCCCCCOC1=CC=CC2=C1C(=O)N(C2=O)C3CCC(=O)NC3=O |
| Reference | [1]. Daniel A. HARKI, et al. Compounds that degrade kinases and uses thereof. WO2020247537A1. [2]. Zhang NN, et al. A Thermostable mRNA Vaccine against COVID-19. Cell. 2020;182(5):1271-1283.e16. |
