Thalidomide-O-C8-Boc

• CAT Number: I014948
• CAS Number: 2225148-52-5
• Molecular Formula: C26H34N2O7
• Molecular Weight: 486.56
• Purity: ≥95%
• Synonyms: tert-butyl 9-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]oxynonanoate
• InChI: InChI=1S/C26H34N2O7/c1-26(2,3)35-21(30)13-8-6-4-5-7-9-16-34-19-12-10-11-17-22(19)25(33)28(24(17)32)18-14-15-20(29)27-23(18)31/h10-12,18H,4-9,13-16H2,1-3H3,(H,27,29,31)
• InChIKey: XHFRZVFJJQOBAQ-UHFFFAOYSA-N
• SMILES: CC(C)(C)OC(=O)CCCCCCCCOC1=CC=CC2=C1C(=O)N(C2=O)C3CCC(=O)NC3=O

Thalidomide-O-C8-Boc is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide-O-C8-Boc can be connected to the ligand for protein by a linker to form PROTACs[1].

Reference

[1]. Nathanael S. Gray, et al. Degraders of wee1 kinase. WO2020069105A1.