For research use only. Not for therapeutic Use.
Thalidomide-O-C8-COOH is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide-O-C8-COOH (Cereblon ligand 3) can be connected to the ligand for protein by a linker to form PROTACs[1].
| Catalog Number | I014976 |
| CAS Number | 2225148-51-4 |
| Synonyms | 9-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]oxynonanoic acid |
| Molecular Formula | C22H26N2O7 |
| Purity | ≥95% |
| InChI | InChI=1S/C22H26N2O7/c25-17-12-11-15(20(28)23-17)24-21(29)14-8-7-9-16(19(14)22(24)30)31-13-6-4-2-1-3-5-10-18(26)27/h7-9,15H,1-6,10-13H2,(H,26,27)(H,23,25,28) |
| InChIKey | JDVPWEYIVOQCDX-UHFFFAOYSA-N |
| SMILES | C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)OCCCCCCCCC(=O)O |
| Reference | [1]. Nathanael S. Gray, et al. Degraders of wee1 kinase. WO2020069105A1. |
