Thalidomide-O-PEG2-propargyl

• CAT Number: I017616
• CAS Number: 2098487-52-4
• Molecular Formula: C₂₀H₂₀N₂O₇
• Molecular Weight: 400.38
• Purity: ≥95%
• Target: Autophagy

Thalidomide-O-PEG2-propargyl (Cat.No:I017616) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology.

Reference

[1]. Wurz RP, et al. A “Click Chemistry Platform” for the Rapid Synthesis of Bispecific Molecules for Inducing Protein Degradation. J Med Chem. 2018 Jan 25;61(2):453-461.