Thalidomide-propargyl

• CAT Number: I017617
• CAS Number: 2098487-39-7
• Molecular Formula: C₁₆H₁₂N₂O₅
• Molecular Weight: 312.28
• Purity: ≥95%
• Target: Autophagy

Thalidomide-propargyl (Cat.No:I017617) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide-propargyl can be connected to the ligand for protein by a linker to form the IMiD containing PROTACs.

Reference

[1]. Wurz RP, et al. A “Click Chemistry Platform” for the Rapid Synthesis of Bispecific Molecules for Inducing Protein Degradation. J Med Chem. 2018 Jan 25;61(2):453-461.