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148-79-8-Thiabendazole Thiabendazole

Thiabendazole

For research use only. Not for therapeutic Use.

  • CAT Number: A000403
  • CAS Number: 148-79-8
  • Molecular Formula: C₁₀H₇N₃S
  • Molecular Weight: 201.25
  • Purity: ≥95%
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Related Small Molecules: Alogliptin     N-(4’-Cyano[1,1’-biphenyl]-4-yl)-N’-[4-(3H-imidazo[4,5-b]pyridin-7-yl)phenyl] Urea     RYL-552    

Thiabendazole（Cat No.:A000403）is a broad-spectrum antifungal and antiparasitic agent commonly used to treat parasitic infections such as strongyloidiasis and trichinosis. It works by inhibiting the enzyme fumarate reductase, which is essential for the energy metabolism of parasites, ultimately leading to their death. Thiabendazole is also used as a post-harvest fungicide in agriculture to protect fruits and vegetables from fungal contamination. In addition to its antiparasitic properties, it has been investigated for antiangiogenic and anticancer activities, making it a versatile compound in both medical and agricultural fields.


Catalog Number A000403
CAS Number 148-79-8
Synonyms

148-79-8; Tiabendazole; Mintezol; Equizole; Mintesol

Molecular Formula C₁₀H₇N₃S
Purity ≥95%
Target Anti-infection
Storage -20°C
IUPAC Name 4-(1H-benzimidazol-2-yl)-1,3-thiazole
InChI InChI=1S/C10H7N3S/c1-2-4-8-7(3-1)12-10(13-8)9-5-14-6-11-9/h1-6H,(H,12,13)
InChIKey WJCNZQLZVWNLKY-UHFFFAOYSA-N
SMILES C1=CC=C2C(=C1)NC(=N2)C3=CSC=N3
Reference

1: Papadopoulou ES, Genitsaris S, Omirou M, Perruchon C, Stamatopoulou A,
Ioannides I, Karpouzas DG. Bioaugmentation of thiabendazole-contaminated soils
from a wastewater disposal site: Factors driving the efficacy of this strategy
and the diversity of the indigenous soil bacterial community. Environ Pollut.
2017 Oct 16;233:16-25. doi: 10.1016/j.envpol.2017.10.021. [Epub ahead of print]
PubMed PMID: 29049942.
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2: Yilmaz E, Ramünke S, Demeler J, Krücken J. Comparison of constitutive and
thiabendazole-induced expression of five cytochrome P450 genes in fourth-stage
larvae of Haemonchus contortus isolates with different drug susceptibility
identifies one gene with high constitutive expression in a multi-resistant
isolate. Int J Parasitol Drugs Drug Resist. 2017 Oct 7;7(3):362-369. doi:
10.1016/j.ijpddr.2017.10.001. [Epub ahead of print] PubMed PMID: 29035734; PubMed
Central PMCID: PMC5645160.

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3: Abassi AJ, Mohamadnia A, Parhiz SA, Azizi Moghadam N, Bahrami N. Cytotoxic
Effect of Thiabendazole on Hn5 Head and Neck Squamous Cell Carcinoma Cell Line. J
Dent (Shiraz). 2017 Sep;18(3):219-226. PubMed PMID: 29034278; PubMed Central
PMCID: PMC5634363.

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4: Feng J, Hu Y, Grant E, Lu X. Determination of thiabendazole in orange juice
using an MISPE-SERS chemosensor. Food Chem. 2018 Jan 15;239:816-822. doi:
10.1016/j.foodchem.2017.07.014. Epub 2017 Jul 8. PubMed PMID: 28873639.

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5: Zhang P, Tian J, Rustum A. Development and Validation of a Fast
Stability-Indicating Ion-Paired Reversed-Phase HPLC Method for the Assay of
Thiabendazole and Estimation of Its Related Compounds. J AOAC Int. 2017 Jan
1;100(1):74-81. doi: 10.5740/jaoacint.16-0242. PubMed PMID: 28825538.
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6: Perruchon C, Pantoleon A, Veroutis D, Gallego-Blanco S, Martin-Laurent F,
Liadaki K, Karpouzas DG. Characterization of the biodegradation, bioremediation
and detoxification capacity of a bacterial consortium able to degrade the
fungicide thiabendazole. Biodegradation. 2017 Dec;28(5-6):383-394. doi:
10.1007/s10532-017-9803-z. Epub 2017 Jul 28. PubMed PMID: 28755318.
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7: de Oliveira Neto OF, Arenas AY, Fostier AH. Sorption of thiabendazole in
sub-tropical Brazilian soils. Environ Sci Pollut Res Int. 2017
Jul;24(19):16503-16512. doi: 10.1007/s11356-017-9226-8. Epub 2017 May 29. PubMed
PMID: 28555395.

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8: Sun Q, He J, Yang H, Li S, Zhao L, Li H. Analysis of binding properties and
interaction of thiabendazole and its metabolite with human serum albumin via
multiple spectroscopic methods. Food Chem. 2017 Oct 15;233:190-196. doi:
10.1016/j.foodchem.2017.04.119. Epub 2017 Apr 20. PubMed PMID: 28530565.
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9: García-Fernández M, Díaz-álvarez M, Martín-Esteban A. Molecularly imprinted
magnetic nanoparticles for the micro solid-phase extraction of thiabendazole from
citrus samples. J Sep Sci. 2017 Jun;40(12):2638-2644. doi:
10.1002/jssc.201700321. Epub 2017 May 30. PubMed PMID: 28474776.

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10: Oliveira AM, Loureiro HC, de Jesus FF, de Jesus DP. Electromembrane
extraction and preconcentration of carbendazim and thiabendazole in water samples
before capillary electrophoresis analysis. J Sep Sci. 2017 Apr;40(7):1532-1539.
doi: 10.1002/jssc.201601305. Epub 2017 Mar 7. PubMed PMID: 28165201.

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