Thiamet G

• CAT Number: I000110
• CAS Number: 1009816-48-1
• Molecular Formula: C9H16N2O4S
• Molecular Weight: 248.3
• Purity: ≥95%
• Synonyms: 2-(ethylamino)-3aR,6S,7R,7aR-tetrahydro-5R-(hydroxymethyl)-5H-pyrano[3,2-d]thiazole-6,7-diol
• Target: Autophagy
• Solubility: DMSO: ≥ 45 mg/mL
• Storage: -20°C
• IC50: 21 nM [1]
• InChIKey: PPAIMZHKIXDJRN-FMDGEEDCSA-N

Thiamet G (CAT: I000110) is a potent and selective inhibitor of O-GlcNAcase, an enzyme responsible for removing O-linked N-acetylglucosamine (O-GlcNAc) modifications from proteins. By inhibiting O-GlcNAcase, Thiamet G increases the levels of protein O-GlcNAcylation, which plays important roles in cellular processes such as signaling, transcription, and protein degradation. Thiamet G has been used as a tool compound in research to investigate the functional consequences of altered protein O-GlcNAcylation and to explore its potential therapeutic applications in diseases such as cancer, neurodegenerative disorders, and diabetes.

Reference

[1]. Yuzwa SA, et al. Increasing O-GlcNAc slows neurodegeneration and stabilizes tau against aggregation. Nat Chem Biol. 2012 Feb 26;8(4):393-9.
[2]. Andrés-Bergós J, et al. The increase in O-linked N-acetylglucosamine protein modification stimulates chondrogenic differentiation both in vitro and in vivo. J Biol Chem. 2012 Sep 28;287(40):33615-28.
[3]. Ding N, et al. Thiamet-G-mediated inhibition of O-GlcNAcase sensitizes human leukemia cells to microtubule-stabilizing agent paclitaxel. Biochem Biophys Res Commun. 2014 Oct 24;453(3):392-7.