For research use only. Not for therapeutic Use.
Thiamphenicol（Cat No.:A000283）is a broad-spectrum antibiotic related to chloramphenicol, effective against a range of Gram-positive and Gram-negative bacteria. Known for its bacteriostatic action, it inhibits protein synthesis by binding to bacterial ribosomes, halting growth. Thiamphenicol is often used in veterinary medicine and in human cases of respiratory and genitourinary infections. Unlike chloramphenicol, it has a reduced risk of bone marrow toxicity, making it a safer alternative in specific settings. Its efficacy against resistant bacterial strains makes it valuable in regions where antimicrobial resistance is a significant concern.
| Catalog Number | A000283 |
| CAS Number | 15318-45-3 |
| Synonyms | Thiophenicol |
| Molecular Formula | C12H15Cl2NO5S |
| Purity | ≥95% |
| Target | Beta-lactamase |
| Storage | -20°C |
| IUPAC Name | 2,2-dichloro-N-[(1R,2R)-1,3-dihydroxy-1-(4-methylsulfonylphenyl)propan-2-yl]acetamide |
| InChI | InChI=1S/C12H15Cl2NO5S/c1-21(19,20)8-4-2-7(3-5-8)10(17)9(6-16)15-12(18)11(13)14/h2-5,9-11,16-17H,6H2,1H3,(H,15,18)/t9-,10-/m1/s1 |
| InChIKey | OTVAEFIXJLOWRX-NXEZZACHSA-N |
| SMILES | CS(=O)(=O)C1=CC=C(C=C1)[C@H]([C@@H](CO)NC(=O)C(Cl)Cl)O |
| Reference | <p>Duck, P. D., and J. R. Dillon. /Effects of Thiamphenicol and Chloramphenicol in Inhibiting Neisseria Gonorrhoeae Isolates./ <em>Antimicrobial Agents and Chemotherapy</em> 14.5 (1978): 788-90. <em>www.ncbi.gov</em>. 26 July 1978. Web. 21 Aug. 2012.</p><p>Mayer, Gene, Dr. /Antibiotics – Protein Synthesis, Nucleic Acid Synthesis, and Metabolism./ University of South Carolina School of Medicine. Web. 21 Aug. 2012.</p><p>Meynier V. and Arnould M.F., 1989, Compared Effectiveness of Antibiotic Treatments and Shoot Tip Culture on Bacterial Decontamination of an <em>in vitro</em> Propagated Clone of Hybrid Walnut (Juglans nigra x J. regia). Biologia Plantarum (PRAHA) 31 (4): 269-275. 1989</p></span></p> |
