Thiazovivin（Cat No.:I000870）is a small molecule inhibitor that enhances cell survival and proliferation by inhibiting Rho-associated protein kinase (ROCK). It plays a critical role in promoting cell adhesion, reducing apoptosis, and improving the reprogramming efficiency of induced pluripotent stem cells (iPSCs). By modulating the cytoskeleton and improving cell-cell interactions, Thiazovivin is widely used in stem cell research to enhance the viability and growth of cultured cells. Its ability to improve cellular reprogramming and maintenance makes it valuable for regenerative medicine, tissue engineering, and stem cell biology applications.
| Catalog Number | I000870 |
| CAS Number | 1226056-71-8 |
| Synonyms | N-benzyl-2-(pyrimidin-4-ylamino)-1,3-thiazole-4-carboxamide |
| Molecular Formula | C₁₅H₁₃N₅OS |
| Purity | ≥95% |
| Target | ROCK |
| Solubility | 10 mM in DMSO |
| Storage | -20°C |
| IC50 | 0.5 μM |
| IUPAC Name | N-benzyl-2-(pyrimidin-4-ylamino)-1,3-thiazole-4-carboxamide |
| InChI | InChI=1S/C15H13N5OS/c21-14(17-8-11-4-2-1-3-5-11)12-9-22-15(19-12)20-13-6-7-16-10-18-13/h1-7,9-10H,8H2,(H,17,21)(H,16,18,19,20) |
| InChIKey | DOBKQCZBPPCLEG-UHFFFAOYSA-N |
| SMILES | C1=CC=C(C=C1)CNC(=O)C2=CSC(=N2)NC3=NC=NC=C3 |
| Reference | </br>1:[Effect of a new ROCK inhibitor thiazovivin on the morphology and function of human corneal endothelial cells]. Wu QN, Ling YZ, Ouyang C, Xie LJ, Huang T.Zhonghua Yan Ke Za Zhi. 2016 Sep 11;52(9):686-92. doi: 10.3760/cma.j.issn.0412-4081.2016.09.010. Chinese. PMID: 27647250 </br>2:Thiazovivin, a Rho kinase inhibitor, improves stemness maintenance of embryo-derived stem-like cells under chemically defined culture conditions in cattle. Park S, Kim D, Jung YG, Roh S.Anim Reprod Sci. 2015 Oct;161:47-57. doi: 10.1016/j.anireprosci.2015.08.003. Epub 2015 Aug 15. PMID: 26307658 </br>3:Reprogramming of endometrial adult stromal cells in the presence of a ROCK inhibitor, thiazovivin, could obtain more efficient iPSCs. Mohseni R, Shoae-Hassani A, Verdi J.Cell Biol Int. 2015 May;39(5):515-8. doi: 10.1002/cbin.10411. Epub 2015 Mar 15. PMID: 25490878 |
