For research use only. Not for therapeutic Use.
Thiethylperazine(Cat No.: M050663) is a medication primarily used as an antiemetic to prevent nausea and vomiting, particularly in patients undergoing chemotherapy or surgery. It is a dopamine antagonist, specifically blocking D2 receptors in the brain’s chemoreceptor trigger zone, thereby reducing the sensation of nausea. Thiethylperazine also has antipsychotic properties, though it is not typically used for this purpose due to its sedative effects. Common side effects include drowsiness, dizziness, and potential extrapyramidal symptoms. It is generally well-tolerated when used for short-term treatment.
| Catalog Number | M050663 |
| CAS Number | 1420-55-9 |
| Molecular Formula | C22H29N3S2 |
| Purity | ≥95% |
| Target | Neuronal Signaling |
| Storage | -20°C |
| IUPAC Name | 2-ethylsulfanyl-10-[3-(4-methylpiperazin-1-yl)propyl]phenothiazine |
| InChI | InChI=1S/C22H29N3S2/c1-3-26-18-9-10-22-20(17-18)25(19-7-4-5-8-21(19)27-22)12-6-11-24-15-13-23(2)14-16-24/h4-5,7-10,17H,3,6,11-16H2,1-2H3 |
| InChIKey | XCTYLCDETUVOIP-UHFFFAOYSA-N |
| SMILES | CCSC1=CC2=C(C=C1)SC3=CC=CC=C3N2CCCN4CCN(CC4)C |
| Reference | </br>1:[Noncardiogenic pulmonary edema in the course of poisoning with clozapine, ketoprofen and thiethylperazine]. Majewska M, Kołodziej M, Szponar J, Drelich G, Danielewicz P, Kostek H.Przegl Lek. 2012;69(8):618-20. Polish. PMID: 23243946 </br>2:Anaphylactic reaction and unrelated, subsequent, known side effects during therapy with thiethylperazine. Rossetti G, Livio F, Roulet E, Hofer MF.Pediatr Allergy Immunol. 2005 Aug;16(5):453-5. PMID: 16101941 </br>3:Thiethylperazine-induced parkinsonism: in vivo demonstration of dopamine D2 receptors blockade. Briani C, Cagnin A, Chierichetti F, Tiberio M, Battistin L, Pizzolato G.Eur J Neurol. 2004 Oct;11(10):709-10. PMID: 15469457 </br>4:Case-control study of teratogenic potential of thiethylperazine, an anti-emetic drug. Czeizel AE, Vargha P.BJOG. 2003 May;110(5):497-9. PMID: 12742335 Free Article</br>5:Subacute cutaneous lupus erythematosus associated with cinnarizine and thiethylperazine therapy. Toll A, Campo-Pisa P, González-Castro J, Campo-Voegeli A, Azón A, Iranzo P, Lecha M, Herrero C.Lupus. 1998;7(5):364-6. PMID: 9696142 </br>6:Incompatibility of ketorolac tromethamine with haloperidol lactate and thiethylperazine maleate. Mendenhall A, Hoyt DB.Am J Hosp Pharm. 1994 Dec 1;51(23):2964. No abstract available. PMID: 7879809 </br>7:[Dyskinesis after a single dose of thiethylperazine during the first trimester of pregnancy]. Budrewicz S, Ejma M.Pol Tyg Lek. 1994 Feb 21-28;49(8-9):205-6. Polish. PMID: 8084830 </br>8:Thiethylperazine treatment of gastroparesis diabeticorum. Lossos IS, Mevorach D, Oren R.Ann Pharmacother. 1992 Jul-Aug;26(7-8):1016. No abstract available. PMID: 1504386 </br>9:Chronic hemidystonia following acute dystonic reaction to thiethylperazine. Jiménez-Jiménez FJ, Vazquez A, Garcia-Ruiz P, Garcia-Urra D, De Seijas EV.J Neurol Neurosurg Psychiatry. 1991 Jun;54(6):562. No abstract available. PMID: 1880525 Free PMC Article</br>10:The antiemetic efficacy of thiethylperazine and methylprednisolone versus thiethylperazine and placebo in breast cancer patients treated with adjuvant chemotherapy (fluorouracil, doxorubicin and cyclophosphamide). A randomized, double-blind, cross-over trial. Diaz-Rubio E, Martin M, Rosell R, Valerdi JJ, Gonzalez-Larriba JL, Barriga JJ.Acta Oncol. 1991;30(3):339-42. PMID: 2036244 |
