For research use only. Not for therapeutic Use.
Thio-TEPA（Cat No.:I003904）, also known as Thioplex or Tiofosfamid, is an alkylating agent primarily used in the treatment of cancer. This molecule possesses a tetrahedral phosphorus structure and is structurally similar to phosphate compounds. Thio-TEPA works by binding to DNA and interfering with its replication, ultimately leading to the destruction of cancer cells. It is commonly utilized in chemotherapy regimens for various cancers, including ovarian, breast, and bladder cancer. Thio-TEPA’s alkylating properties and structural resemblance to phosphate make it an effective tool in cancer treatment.
| Catalog Number | I003904 |
| CAS Number | 52-24-4 |
| Molecular Formula | C6H12N3PS |
| Purity | ≥95% |
| Target | DNA Alkylating |
| Solubility | 10 mM in DMSO |
| Storage | 2-8°C |
| IUPAC Name | tris(aziridin-1-yl)-sulfanylidene-λ5-phosphane |
| InChI | InChI=1S/C6H12N3PS/c11-10(7-1-2-7,8-3-4-8)9-5-6-9/h1-6H2 |
| InChIKey | FOCVUCIESVLUNU-UHFFFAOYSA-N |
| SMILES | C1CN1P(=S)(N2CC2)N3CC3 |
| Reference | </br>1:Sensitivity of p53-deficient cells to oxaliplatin and thio-TEPA (N, N/’, N/ triethylenethiophosphoramide). Seo YR, Chen EI, Smith ML.Breast Cancer Res Treat. 2002 Apr;72(3):255-63. PMID: 12058967 </br>2:A pharmacokinetic and clinical evaluation of thio-TEPA in combination with cisplatin as first-line chemotherapy for advanced epithelial ovarian carcinoma. Hagen B, Onsrud M, Dale O.Int J Gynecol Cancer. 1999 Mar;9(2):110-116. PMID: 11240751 </br>3:Gender aspects of liver slice incubations with N,N,N-triethylene-thiophosphamide (Thio-TEPA) in rats and mice. Dale O, Thommesen L, Mortensen B, Hagen B.Pharmacol Toxicol. 1999 Mar;84(3):122-4. PMID: 10193672 </br>4:[A comparative study of thio-tepa and mitomycin C in the treatment of pterygium. Preliminary results]. Ngoy D, Kayembe L.J Fr Ophtalmol. 1998 Feb;21(2):96-102. French. PMID: 9759389 Free Article</br>5:In the search for new anticancer drugs. 26. A comparison of anticancer activities of several TEPA, thio-TEPA, Seleno-TEPA, and azetidine analogs, including congeners containing an aminoxyl moiety. Sosnovsky G, Lukszo J, Konieczny M, Purgstaller K, Laib F.J Pharm Sci. 1994 Jul;83(7):982-8. PMID: 7525922 </br>6:Meiosis and chromosomal effects of thio-TEPA in the ovarian cells of Aedes aegypti. Puttaraju HP.Cytobios. 1994;78(315):221-6. PMID: 8001399 </br>7:Activation of thio-tepa cytotoxicity toward human breast-cancer cells by hepatic cytochrome-p450. Ng S, Waxman D.Int J Oncol. 1993 May;2(5):731-8. PMID: 21573617 </br>8:[Effect of antenatal action of Thio-Tepa on spermatogenesis of mature 101/N and CBA mice]. Khil/’kevich LV, Kurilo LF, Zhubinskaia VP, Lil/’p IG.Biull Eksp Biol Med. 1992 Sep;114(9):307-8. Russian. PMID: 1477370 </br>9:[High-dose thio-TEPA with escalating doses of epirubicin and autologous hematopoietic stem cell transplant for refractory cancers]. Mukaiyama T, Ogawa M, Horikoshi N, Inoue K, Aiba K, Matsuoka A, Matsumura T, Ogihara A, Sumida T.Gan To Kagaku Ryoho. 1992 Feb;19(2):189-94. Japanese. PMID: 1371047 </br>10:A prospective randomized study of prophylaxis of tumor recurrence following transurethral resection of superficial bladder cancer–intravesical thio-TEPA versus oral UFT. Hirao Y, Okajima E, Ozono S, Samma S, Sasaki K, Hiramatsu T, Babaya K, Watanabe S, Maruyama Y.Cancer Chemother Pharmacol. 1992;30 Suppl:S26-30. PMID: 1394812 |
