Thioflavin T

• CAT Number: I013117
• CAS Number: 2390-54-7
• Molecular Formula: C₁₇H₁₉ClN₂S
• Molecular Weight: 318.86
• Purity: ≥95%
• Target: Amyloid-β
• Solubility: H2O: ≥ 30 mg/mL
• IUPAC Name: 4-(3,6-dimethyl-1,3-benzothiazol-3-ium-2-yl)-N,N-dimethylaniline;chloride
• InChI: InChI=1S/C17H19N2S.ClH/c1-12-5-10-15-16(11-12)20-17(19(15)4)13-6-8-14(9-7-13)18(2)3;/h5-11H,1-4H3;1H/q+1;/p-1
• InChIKey: JADVWWSKYZXRGX-UHFFFAOYSA-M
• SMILES: CC1=CC2=C(C=C1)[N+](=C(S2)C3=CC=C(C=C3)N(C)C)C.[Cl-]

Thioflavin T（Cat No.:I013117）is a fluorescent dye commonly used in biochemistry and neuroscience for detecting amyloid fibrils, which are associated with neurodegenerative diseases like Alzheimer’s and Parkinson’s. It binds specifically to β-sheet-rich structures, emitting a strong fluorescence upon binding to amyloid aggregates. Thioflavin T is widely used in research to study protein misfolding and aggregation, providing valuable insights into disease mechanisms. It is also utilized in diagnostic assays and screening for amyloid-related conditions. The compound’s ability to detect amyloid plaques makes it a useful tool in drug development and biomarker research.

Reference

[1]. Khurana R, et al. Mechanism of thioflavin T binding to amyloid fibrils. J Struct Biol. 2005 Sep;151(3):229-38.