For research use only. Not for therapeutic Use.
Thiol-PEG2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
| Catalog Number | I037234 |
| CAS Number | 1379649-73-6 |
| Synonyms | 3-[2-(2-sulfanylethoxy)ethoxy]propanoic acid |
| Molecular Formula | C7H14O4S |
| Purity | ≥95% |
| InChI | InChI=1S/C7H14O4S/c8-7(9)1-2-10-3-4-11-5-6-12/h12H,1-6H2,(H,8,9) |
| InChIKey | LVZZPXCJOJFHTI-UHFFFAOYSA-N |
| SMILES | C(COCCOCCS)C(=O)O |
| Reference | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
