For research use only. Not for therapeutic Use.
Thiol-PEG6-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
| Catalog Number | I016351 |
| CAS Number | 194425-46-2 |
| Synonyms | 2-[2-[2-[2-[2-(2-sulfanylethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethanol |
| Molecular Formula | C12H26O6S |
| Purity | ≥95% |
| InChI | InChI=1S/C12H26O6S/c13-1-2-14-3-4-15-5-6-16-7-8-17-9-10-18-11-12-19/h13,19H,1-12H2 |
| InChIKey | RBHVCADZZSNWRE-UHFFFAOYSA-N |
| SMILES | C(COCCOCCOCCOCCOCCS)O |
| Reference | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
