For research use only. Not for therapeutic Use.
Thiolutin（Cat No.:R056383）is a potent, small-molecule inhibitor of RNA polymerase and protein synthesis, primarily targeting bacterial transcription. It inhibits bacterial growth by blocking RNA polymerase elongation, making it effective against a range of Gram-positive and Gram-negative bacteria. Thiolutin also has anti-inflammatory and anti-fibrotic properties, with potential therapeutic applications in autoimmune diseases and fibrosis. In addition to its antimicrobial activity, it serves as a valuable tool in molecular research, particularly in studying bacterial transcription mechanisms and RNA processing. It has also been explored for its potential in cancer therapy due to its cellular effects.
| CAS Number | 87-11-6 |
| Synonyms | N-(4,5-Dihydro-4-methyl-5-oxo-1,2-dithiolo[4,3-b]pyrrol-6-yl)acetamide; 6-Acetamido-4-methyl-1,2-dithiolo[4,3-b]pyrrol-5(4H)-one; 3-Acetamido-5-methylpyrrolin-4-one[4,3-d]-1,2-dithiole; Acetopyrrothin; N-(4,5-Dihydro-4-methyl-5-oxo-1,2-dithiolo[4,3- |
| Molecular Formula | C8H8N2O2S2 |
| Purity | ≥95% |
| Target | Metabolic Enzyme/Protease |
| Solubility | Limited solubility |
| Storage | Desiccate at -20°C |
| IUPAC Name | N-(4-methyl-5-oxodithiolo[4,3-b]pyrrol-6-yl)acetamide |
| InChI | InChI=1S/C8H8N2O2S2/c1-4(11)9-6-7-5(3-13-14-7)10(2)8(6)12/h3H,1-2H3,(H,9,11) |
| InChIKey | MHMRAFONCSQAIA-UHFFFAOYSA-N |
| SMILES | CC(=O)NC1=C2C(=CSS2)N(C1=O)C |
| Reference | Studies on a common hydrolysis product of thiolutin and aureothricin. Celmer W.D. and Solomons I.A. Antibiotics Annual 1953, 622.<br/><br/>Anticancer property of dithiolopyrrolones. Webster J.M. et al. 2000, US Patent 6,020,360.<br/><br/>Thiolutin inhibits yeast ribonucleic acid polymerases. Tipper D.J. J. Bacteriol. 1973, 116, 245.<br/><br/>Thiolutin, an inhibitor of HUVEC adhesion to vitronectin, reduces paxillin in HUVECs and suppresses tumor cell-induced angiogenesis. Minamiguchi K. Int. J. Cancer 2001, 93, 307.<br/><br/>Thiolutin, an inhibitor of macromolecular synthesis in Saccharomyces cerevisiae. Mode of action. Jimenez A. Antimicrob Agents Chemother. 1973, 3, 729.</span></p> |
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