For research use only. Not for therapeutic Use.
Thiolutin(Cat No.:R056383)is a potent, small-molecule inhibitor of RNA polymerase and protein synthesis, primarily targeting bacterial transcription. It inhibits bacterial growth by blocking RNA polymerase elongation, making it effective against a range of Gram-positive and Gram-negative bacteria. Thiolutin also has anti-inflammatory and anti-fibrotic properties, with potential therapeutic applications in autoimmune diseases and fibrosis. In addition to its antimicrobial activity, it serves as a valuable tool in molecular research, particularly in studying bacterial transcription mechanisms and RNA processing. It has also been explored for its potential in cancer therapy due to its cellular effects.
CAS Number | 87-11-6 |
Synonyms | N-(4,5-Dihydro-4-methyl-5-oxo-1,2-dithiolo[4,3-b]pyrrol-6-yl)acetamide; 6-Acetamido-4-methyl-1,2-dithiolo[4,3-b]pyrrol-5(4H)-one; 3-Acetamido-5-methylpyrrolin-4-one[4,3-d]-1,2-dithiole; Acetopyrrothin; N-(4,5-Dihydro-4-methyl-5-oxo-1,2-dithiolo[4,3- |
Molecular Formula | C8H8N2O2S2 |
Purity | ≥95% |
Target | Metabolic Enzyme/Protease |
Solubility | Limited solubility |
Storage | Desiccate at -20°C |
IUPAC Name | N-(4-methyl-5-oxodithiolo[4,3-b]pyrrol-6-yl)acetamide |
InChI | InChI=1S/C8H8N2O2S2/c1-4(11)9-6-7-5(3-13-14-7)10(2)8(6)12/h3H,1-2H3,(H,9,11) |
InChIKey | MHMRAFONCSQAIA-UHFFFAOYSA-N |
SMILES | CC(=O)NC1=C2C(=CSS2)N(C1=O)C |
Reference | Studies on a common hydrolysis product of thiolutin and aureothricin. Celmer W.D. and Solomons I.A. Antibiotics Annual 1953, 622.<br/><br/>Anticancer property of dithiolopyrrolones. Webster J.M. et al. 2000, US Patent 6,020,360.<br/><br/>Thiolutin inhibits yeast ribonucleic acid polymerases. Tipper D.J. J. Bacteriol. 1973, 116, 245.<br/><br/>Thiolutin, an inhibitor of HUVEC adhesion to vitronectin, reduces paxillin in HUVECs and suppresses tumor cell-induced angiogenesis. Minamiguchi K. Int. J. Cancer 2001, 93, 307.<br/><br/>Thiolutin, an inhibitor of macromolecular synthesis in Saccharomyces cerevisiae. Mode of action. Jimenez A. Antimicrob Agents Chemother. 1973, 3, 729.</span></p> |